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Wednesday, May 17, 2006

Anti-aging effect of anti-lipolytic drugs

Something for Michael to look into I guess. Nicotinic acid is an anti-lipolytic vitamin.

 Exp Gerontol. 2004 Jul;39(7):1061-7.  Related Articles, Links  

Anti-aging effects of anti-lipolytic drugs.

Donati A, Cavallini G, Carresi C, Gori Z, Parentini I, Bergamini E.

Centro di Ricerca Interdipartimentale sull'Invecchiamento, Universita di Pisa, Via Roma 55, 56126 Pisa, Italy.

Genetic disruption of insulin and insulin-like signaling pathways may extend lifespan. Hyperinsulinemia and insulin resistance may accelerate aging. The hypothesis was tested that a once-a-week life-long inhibition of insulin secretion by the administration of anti-lipolytic drugs might have anti-aging effects. Groups of 3-month-old male Sprague-Dawley rats were (a) given standard laboratory food ad libitum (AL); (b) fed AL 6 days and fasted 1 day every week (FW); (c) fed AL every other day (E! OD), (d) fed like FW and given Acipimox (50 mg/kg b.w.) on the day of fasting (FWA) by the gastric tube. The AL, FW and EOD groups received saline intragastrically. Treatment with ACIPIMOX transiently decreased plasma free fatty acids, glucose and insulin and increased valine plasma levels, and had no long-term effect on food consumption and body weight. By age 6, 12 and 24 months subgroups were taken and the age-related changes in liver dolichol and autophagic proteolysis-which are correlated with life-expectancy-were measured. Liver dolichol levels increased and autophagic proteolysis decreased in mature and older AL rats; EOD and FWA fully counteracted these changes; FW rats had significant but smaller beneficial effects. It is concluded that life-long weekly-repeated transient inhibition of insulin secretion by antilipolytic drugs may have an anti-aging effect, additive to the anti-aging effect of a milder caloric restriction. Speculation is that transien! tly lower plasma insulin levels might stimulate the anti-aging cell-r epair mechanism autophagy, which has longer lasting effects on cell housekeeping.

PMID: 15236765 [PubMed - in process]

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